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    Archived pages: 9 . Archive date: 2013-12.

  • Title: Home
    Descriptive info: .. Home.. Our Services.. Disclaimer.. Contact.. The Company.. Vaecgene biotech is a specialized service provider for the pharmaceutical industry but also for researchers.. We provide the tools necessary to generate new drugs and therapeutics.. We will deliver new targets for the generation of therapeutic and diagnostic antibodies dedicated to the treatment of tumours, chronical infections and autoimmune diseases.. The company is a spin-off of the.. GSF-National Research Center for Environment and Health.. and the.. Ludwig-Maximilians-Universitaet.. in Munich / Germany.. Vaecgene provides different biological  ...   be a valuable partner to our customers.. Technology Platforms.. EBV.. is a human herpes virus with unique biological features.. Our long-standing experience allows us to offer to our customers a series of interesting and useful services like the.. generation of permanent B-cell lines,.. sustained protein expression in B-cells,.. quantification of the immune status / immunosuppression.. quantification of infectious EBV in biological fluids.. Drug testing:.. We have developed unique tools for the quantification of immunosuppressive and immunotoxic properties of drugs in humans and non-human primates..

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  • Title: Services
    Descriptive info: Services.. EBV-related Services.. Generation of immortalized B cell lines (LCLs).. Regression assays.. Generation of antigen-expressing LCLs.. Generation of LCLs in primates.. Immunotoxicity /.. Immunosuppression.. Immunological assays in humans and non-human primates.. ELISA and ELISPOT, FACS analysis.. Virus capture assays.. Quantification of immunosuppression.. Quantification of lymphocyrytoviruses.. back..

    Original link path: /services.html
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  • Title: Home
    Descriptive info: In an judgement on May 12th, 1998, the Landgericht Hamburg decided that the publication of a link can imply liability for the contents of the page linked to and that this can only be foreclosed by explicitly dissocating from these contents.. Vaecgene uses links in its internet representation; for  ...   that we do not have any influence on the contents of the pages we link to.. We therefore explicitly dissociate from the contents of all these pages.. This is valid for all links used on our pages as well as for contents of pages these links may lead to..

    Original link path: /disclaimer.html
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  • Title: Contact
    Descriptive info: Anbieterkennzeichnung.. Contact Us.. Phone.. ++4989-7099296.. Email.. info@vaecgene.. de.. Postal Address.. Vaecgene Biotech.. Marchioninistr.. 25.. 81377 Munich.. Germany.. Vaecgene is situated in München / Martinsried which is the biggest biotech area in Germany..

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  • Title: EBV
    Descriptive info: AMIDA.. Generation of LCLs.. Cell for Antigen expression.. Packaging Cell Lines.. What is EBV?.. Immunology.. EBV Technologies and Services.. Epstein-Barr-Virus (EBV) is a member of the family herpesviruses.. Almost anyone of us harbors the virus, normally without any clinical symptoms.. EBV is the causative agent of infectious mononucleosis ("mono") and is also associated with different types of human cancer (nasopharyngeal carcinoma, Burkitt's lymphoma, Hodgkin disease).. EBV is also a major cause of morbidity and mortality in immunocompromised hosts after solid organ and bone marrow transplantation.. EBV is also the only known virus capable of infecting human B lymphocytes.. Upon infection, these immune cells are immortalized by the virus and turned into powerful professional antigen presenting cells (APC).. B cell tropism and certain other biological features are unique to EBV and make the virus an interesting gene delivery system.. However, due to the size of its genome, the virus has long been inaccessible to genetic manipulation.. Only recently, a revolutionary genetic system, invented by the founders of Vaecgene, has made EBV a valuable tool for biomedicine.. Today, Vaecgene is the only company in the world with the technical knowhow and exclusive licences to use EBV-derived plasmids for therapy.. The first step to use EBV as a vector system was the establishment of a sytem that allows its genetic manipulation.. Applying these newly established techniques and methods, we generated the first packaging cell line for herpesvirus vectors that can package DNA up to 180kb in size into a viral particle to transduce any gene(s) into B cells of normal or oncogenic human origin.. We offer to our customers the following services relying on our expertise in handling EBV and its derivatives:.. Generation of EBV-immortalized human B Cell Lines (LCLs).. EBV-immortalized B cell lines (LCLs) are a valuable permanent source for almost unlimited amounts of DNA from almost any individual, like it is required for epidemiological and hereditary studies.. Whenever desired, we can establish LCLs (or DNA isolated therefrom) from  ...   Additionally, we offer custom cloning of your gene of interest into our immortalization/presentation vecto.. rs.. EBV packaging Cell Line.. Human B cells (both primary cells and cell lines) are extremly recalcitrant to transfection by chemical or physical means.. We rely on the natural tropism of Epstein Barr-Virus to transport plasmids with high efficiency into these cells.. Based on the human cell line HEK293, we have generated the first (patent-protected) packaging system for Herpesviruses, that allows the production of recombinant infectious EBV particles.. Packageable plasmids are:.. mini-EBVs:.. these plasmids carry all viral genes that are necessary for the immortalization of human B-cells, a feature that is unique to EBV.. Introduce your gene of interest (GOI) onto a mini-EBV in order to generate B cell lines that combine permanent growth with sustained expression of the GOI.. micro-EBVs:.. contain all viral elements for packaging and CMV-driven expression of the GOI in human B cells.. Contain hygromycin or neomycin resistance for selection.. Generation of Antigen specific human T Lymphocytes.. MiniLCLs are mini-EBV infected antigen-presenting cell lines that efficiently induce specific T cell responses in vitro.. Established easily from any donor, miniLCLs constitute a versatile system for the generation of large numbers of T cytotoxic lymphocytes for adoptive cell therapies.. We have constructed mini-EBVs for the treatment of the following clinical conditions:.. Cell mediated immunity is an essential host factor in the control of most diseases, but cancer patients and patients receiving immunosuppression suffer from a defective immune system, unable to mount a tumour-specific immune response.. Outside help may come in the form of adoptive transfer of specific T cells to establish immunity, which is an effective therapy for viral infections and malignancies.. CMV Disease.. CMV is a major clinical problem in immunocompromised patients and responsible for significant morbidity and mortality.. Current treatment of CMV disease includes the administration of Gancyclovir and T cell preparations in vitro since adoptive therapy with such preparations may be of great clinical benefit.. Carcinoma, EBV-associated Lymphoma..

    Original link path: /ebv.html
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  • Title: Drug testing
    Descriptive info: Drug testing in humans and non-human primates.. Quantification of infectious EBV.. Please inquire for detailed informations..

    Original link path: /drugs.html
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  • Title: AMIDA technology
    Descriptive info: The AMIDA Technology.. Overview.. The immune system recognises viruses, bacteria, but also tumour cells as "foreign" by means of specific structures that are not found on healthy cells.. An infection or tumour usually elicits an immune reaction resulting in the activation of specific immune cells (the cellular immune response) and in the production of antibodies (the humoral immune response).. These responses may be triggered by viral or bacterial proteins (such is the case with papilloma virus or tetanus), or by one or more cellular proteins on the surface of tumour cells that may be overly abundant (such as her/2neu on breast cancer cells) or have been changed in some way (as is the case with Mucin-1 on several tumour types).. Antigens on tumour cells can elicit an immune system-triggered response, leading to the generation of antibodies.. Upon binding of these antibodies to specific structures on cell surfaces, a series of immunological processes is initiated, leading to the destruction of the cells.. However, in certain situations (tumours, immune suppression), these lines of defense cannot offer adequate protection, and the immune system must rely on outside help.. This help can be provided e.. g.. in the form of therapeutic antibodies against tumour-specific antigens.. The most direct means to identify such specific target proteins is through proteomic procedures, particularly since the structures that serve as targets (e.. , for therapeutic antibodies) are proteins.. Immanent to AMIDA is an intelligent filtre that simultaneously examins each protein's relevance and allows only a fraction of  ...   Thanks to this immunological filter, we are only identifying targets that are in direct association with the disease.. AMIDA is an unique advancement in functional proteomics and a powerful tool for the identification of new antigens and protein targets for therapeutics.. Combined with state-of-the-art mass spectrometry, AMIDA has demonstrated its potential on different kinds of human cancer as well as on antigens from infectious microorganisms.. By using patient-specific material (like a small tumour biopsy), we evaluate your samples within 2 weeks for specific antigens recognized by the humoral immune system.. Vaecgene is also pursuing a molecular diagnostic approach to the development of cancer tests - the measurement of cancer antibodies in blood.. This approach has several advantages over other technologies.. Cancer-specific antibodies develop very early and usually prior to the detection of tumour marker proteins or palpable tumours; therefore, antibody-based tests are superior to commercially available tumour marker protein blood tests.. In addition, cancer antibodies are found directly in blood and not only on tumour cells, which is a major hurdle to the development of tumour marker protein tests.. Identification of humoral antigens specific for or associated with cancer, infectious diseases or autoimmune diseases.. The process.. Upon submission of your samples, we will perform a duplicate AMIDA search, including electronic imaging, mass spectrometry and database search.. Finally, a summary file is provided which lists all antigens identified.. Upon request, literature searches and bioinformatics can also be performed.. Please contact us for further informations, instructions on sample preparation, and pricing..

    Original link path: /amida.html
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  • Title: Contact
    Descriptive info: Anbieterkennung.. Vaecgene Biotech GmbH.. Geschäftsführer: Dr.. Reinhard Zeidler.. Email: info@vaecgene.. Tel.. : ++4989-7099296..

    Original link path: /anbieterkennung.html
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  • Title: EBV
    Descriptive info: Generation of.. LCLs.. Cells for Antigen.. Expression.. Packaging Cell.. Lines.. Antigen-specific.. T cells.. What is EBV ?.. EBV (Epstein-Barr-Virus) is an ubiquitous human herpesvirus that is transmitted in saliva.. EBV infects human cells with great efficiency and persists life-long in infected individuals.. The virus is associated with different severe diseases:.. Cancer:.. EBV is suggested to be an important co-factor for the development of nasopharyngeal cancer, Hodgkin's disease, Burkitt lymphoma, T cell lymphoma, some types of gastric cancer and smooth-muscle tumors.. The virus is also consistently associated with post-transplant lymphoma (PTLD).. Due to this association,.. the.. World Health Organization (WHO).. classifies.. EBV as a 'class I carcinogen'.. Infectious Mononucleosis (IM):.. A lymphoproliferative disorder that occurs in adolescents and adults upon primary infection with EBV.. Although usually self-limiting, IM sporadically becomes chronic.. Chronic active Epstein-Barr virus infection (CAEBV) is a rare but severe disease with high morbidity and mortality.. CAEBV is characterised by IM-like symptoms, such as fever, hepatosplenomegaly, hepatitis and lymphadenopathy.. Chronic Fatigue Syndrome (CFS):.. CFS is a condition of prolonged debilitating fatigue and tiredness that significantly decreases the patient's ability to participate in ordinary activities.. The hallmark symptoms of CFS are overwhelming fatigue and weakness that make it extremely  ...   it is probably multifactorial.. Researcher suggest that a virus causes CFS, and some suggest that this virus may be EBV since some patients have elevated titers of EBV-specific antibodies and high numbers of infectious EBV particles in their blood.. CFS could be initiated by a viral infection that is complicated by an abnormal immune response in predisposed individuals.. Whereas EBV-specific antibodies can easy to measure,.. quantification of infectious EBV particles in the blood was difficult so far.. This can now be done by means of a.. special indicator cell line.. A recent study reported the beneficial use of the anti-viral drug valacyclovir in CFS patients with persistent EBV infection (.. further reading.. ).. Rheumatoid Arthritis (RA):.. Numerous associatios have been documented between EBV and RA.. Many RA patients have increased values of antibodies against EBV proteins and many whow a serological evidence of reactivated EBV infection.. Although the exact etiology of RA is currently unknown, EBV may be an important co-factor.. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition.. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions..

    Original link path: /ebvinfo.html
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    Archived pages: 9